Drug Blocks HIV In Lab Study, Human Tests Planned - KSWO, Lawton, OK- Wichita Falls, TX: News, Weather, Sports. ABC, 24/7, Telemundo -

Drug Blocks HIV In Lab Study, Human Tests Planned

Posted: Updated:
By MALCOLM RITTER
AP Science Writer

NEW YORK (AP) - Can an experimental drug developed to treat epilepsy block the AIDS virus? A preliminary lab study suggests it's possible, and researchers are eager to try it in people.

Scientists experimented with the drug after uncovering details of how they believe HIV cripples the immune system to bring on AIDS.

When tested in human tissues in the laboratory, the drug "works beautifully" to prevent HIV from destroying key cells of the immune system, said Dr. Warner Greene of the Gladstone Institutes in San Francisco. Those results appear in a paper by Greene and others published online Thursday by the journal Nature.

In that work, and a companion study published in Science, Greene and colleagues focus on how HIV kills vital CD4 cells of the disease-fighting immune system.

Researchers have long known it infects some CD4 cells and turns them into virus-producing factories, killing them in the process. But far more cells die without undergoing that transformation. What is going on in these "bystander"CD4 cells?

The new work provides evidence that HIV enters these cells but fails to produce a full-blown infection, and in response the cells trigger a lethal attack on themselves by the immune system.

It's "more of a suicide than a murder," Greene said. "I believe this is the major mechanism through which CD4 cells are depleted, which is the hallmark of AIDS."

The epilepsy drug, which is not on the market, blocks an enzyme that the research identified as playing a key role in that immune system attack.

Prior studies of the drug in people show it is safe, Greene said. So the researchers are talking to the drug company about testing it in people infected with HIV. No timeline for such studies has been set, he said.

Greene said if such studies are successful, the drug might be used in people whose HIV resists standard drugs. It might also be useful as a temporary treatment to keep HIV at bay for people who can't immediately get standard drugs, he said. It's even possible, he speculated, that the enzyme-blocking drug might help scientists eradicate the virus from the body.

It's not clear yet whether the enzyme-blocking approach will produce a practical therapy for HIV-infected people, said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, who was not involved in the work.

But the new research behind that strategy is "an important advance" toward understanding how HIV kills immune system cells, he said.

__

Online:

Science: http://www.sciencemag.org

Nature: http://www.nature.com/nature

___

Malcolm Ritter can be followed at http://www.twitter.com/malcolmritter

Copyright 2013 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

  • Local NewsLocal NewsMore>>

  • SkyWARN 7 Forecast

    SkyWARN 7 Forecast

    Tuesday, July 29 2014 4:40 AM EDT2014-07-29 08:40:46 GMT
    Clouds With a Few Showers & Storms Today...
    Clouds With a Few Showers & Storms Today...
  • Driver injured in collision

    Driver injured in collision

    Tuesday, July 29 2014 12:08 AM EDT2014-07-29 04:08:42 GMT
     LAWTON, Okla._Two cars collided evening in front of a Lawton hospital after a driver made too wide of a turn.
     LAWTON, Okla._Two cars collided evening in front of a Lawton hospital after a driver made too wide of a turn.
  • Drive-by shooting victim shot in the eye

    Drive-by shooting victim shot in the eye

    Tuesday, July 29 2014 12:04 AM EDT2014-07-29 04:04:17 GMT
     The victim of a drive-by shooting remains hospitalized after he was shot in the eye.
     The victim of a drive-by shooting remains hospitalized after he was shot in the eye.
Powered by WorldNow
KSWO-TV, 1401 SE 60th Street
Lawton, OK 73501

Telephone: (580) 355-7000
Fax: (580) 357-3811
Email: news@kswo.com

All content © Copyright 2000 - 2014 Worldnow and KSWO. All Rights Reserved. For more information on this site, please read our Privacy Policy and Terms of Service.