By CLIFF BRUNT
AP Sports Writer
NORMAN, Okla. (AP) - Baker Mayfield passed for 300 yards and two touchdowns and ran for another score to help No. 9 Oklahoma defeat No. 25 Baylor 45-24 on Saturday.
The Sooners won their seventh in a row overall and 15th straight in Big 12 play. Joe Mixon had 187 yards from scrimmage and Samaje Perine ran for 100 yards and two touchdowns after missing three games with a pulled muscle in his right leg for Oklahoma (8-2, 7-0 Big 12, No. 11 CFP).
Baylor (6-3, 3-3) had hoped to bounce back after last week's 62-22 loss to TCU. Instead, the Bears are on their first 3-game losing streak since the middle of the 2012 season.
Baylor quarterback Seth Russell severely dislocated his left ankle and was carted off the field with 5:48 left in the third quarter. He passed for 148 yards and ran for 70 before getting hurt, but he threw two interceptions and lost a fumble.
Baylor: The Bears continued to fall apart. Their collapse started with a loss to Texas, got much worse against TCU, and now, things look bleak with Russell out. Russell missed much of last season with a broken neck. Backup quarterback Zach Smith completed 6 of 15 passes for 144 yards and a touchdown. The Bears will need to hope Russell's injury isn't as serious as it looked.
Oklahoma: Oklahoma's defense was solid for the third straight week after giving up 59 points and 854 yards against Texas Tech. The Sooners gave up three points against Kansas, then 24 against Iowa State the next game. Baylor gained 504 yards, but Oklahoma's defense forced three critical turnovers. Linebacker Jordan Evans led the way with two sacks and two interceptions.
Baylor hosts Kansas State next Saturday.
Oklahoma travels to West Virginia next Saturday.
More AP college football: www.collegefootball.ap.org
Follow Cliff Brunt on Twitter: http://www.twitter.com/CliffBruntAP .
Copyright 2016 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.